What role does sodium play in vascular dementia?
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Overview
This research study tests how to use brain scans and blood tests together to diagnose the underlying causes of memory problems more accurately, and at an earlier stage than is currently possible. We are interested in detecting early changes in the brain due to vascular (blood vessel) disease and changes that may be associated with Alzheimer’s disease. We will test new Magnetic Resonance Imaging (MRI) methods and blood tests.
Summary
What is the study about?
Vascular dementia, a debilitating condition that impairs memory due to a lack of blood supply to the brain, shares several similarities with Alzheimer’s disease. This makes it difficult for doctors to distinguish between these two diseases. Therefore, a more reliable diagnostic test is urgently required before effective treatment for vascular dementia can be developed.
What are you trying to find out?
We want to find out if measuring sodium using magnetic resonance imaging (MRI) can help better distinguish between earlier stages of these diseases. To investigate this, we will need participants with early-stage vascular dementia (also known as vascular cognitive impairment), early-stage Alzheimer’s disease, or those with no form of dementia. We intend to recruit 19 participants per group (57 participants in total).
Who is it for?
We are looking for participants over 50 years old with one of the following:
- no form of dementia
- a diagnosis of mild cognitive impairment
- a diagnosis of Alzheimer's disease / vascular dementia
What does taking part involve?
You can find out more information about taking part in this study by downloading the key documents at the top of this page.
You’ll need to come in for two visits, roughly one week apart.
Participants will need to:
- Have a blood test
- Undergo an MRI scan
- Complete two cognitive tests
- Have a lumbar puncture (optional)
Why is it important?
You will be helping to change the lives of people with dementia by contributing to important research that could improve how dementia is diagnosed.
How can I find out more?
You can find out more information about taking part in this study by downloading the key documents at the top of this page.
If you are interested in taking part in this study, or have questions for the research team, click the button below to email us:
Meet the researcher
Ross DunneLater Life Psychiatrist and Dementia Specialist
I'm Ross Dunne, a later life psychiatrist and dementia specialist working in GMMH. I am also the clinical director of the Greater Manchester Dementia Research Centre, the region's leading clinical trial unit for the diseases causing dementia. My research focusses on simpler ways to diagnose the underlying causes of dementia, and assessing treatments to help slow dementia or improve symptoms.