About GMDRC

The Greater Manchester Dementia Research Centre (GMDRC) has a 10-year track record of connecting people living with dementia with cutting-edge studies run by industry partners or the National Institute for Health Research (NIHR). We have close links to the University of Manchester through the Faculty of Biology, Medicine and Health and the Geoffrey Jefferson Brain Research Centre (GJBRC).

Locally, with our GM partners, the Manchester Clinical Research Facility and Health Innovation Manchester, we provide the infrastructure and expertise necessary to bring disease-modyfing medications to Greater Manchester.  Together with patients and partners our aim is to be part of a global team that brings the first disease-modifying medications to patients living with dementia. 

We use the state-of-the-art PET-MRI scanner located in St. Mary's Hospital and funded by the Dementias Platform UK to examine the earliest parts of the brain affected by Alzheimer's and other dementias. Nationally, working with the UK Brain Health Network (Bristol, Edinburgh, London, Cambridge, Oxford, Manchester, Newport and Belfast) we aim to bring molecular diagnostics into routine practice in the UK.

Dr Ross Dunne

Unit Director: Dr Ross Dunne

Later Life Psychiatrist and Dementia Research Specialist, GMMH

  • What role does sodium play in vascular dementia?

    We want to find out if measuring sodium using magnetic resonance imaging (MRI) can help better distinguish between vascular dementia and Alzheimer's disease at the earlier stages of these diseases. This research study tests how to use brain scans and blood tests together to diagnose the underlying causes of memory problems more accurately, and at an earlier stage than is currently possible.

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  • ABHAD study logo: The ABHAD study in blue and black font. Underneath in blue: Auditory Biomarkers of Healthy Ageing and Alzheimer's Disease

    The ABHAD study

    Auditory Biomarkers of Healthy Ageing and Alzheimer's Disease

    The ABHAD study is investigating how sounds are processed along the auditory pathway in normal healthy ageing and at various stages in people living with Alzheimer's Disease. This would help us to understand whether early and measurable changes are found in people living with Alzheimer's Disease, which can be used to help us predict who is at risk of developing dementia.

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  • The SABRE study

    Spatial Biomarkers for Early Alzheimer's Disease (SABRE).

    Spatial navigation and memory abilities are controlled by regions of the brain which are the first regions to be affected by Alzheimer’s Disease (AD). The aim of this study is to develop tests of spatial navigation and memory that could be used in routine clinical practice to help diagnose AD in its earliest stages.

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  • The StrataStem study

    Little is known about how and why Alzheimer's disease develops. Diagnosis of Alzheimer's disease is difficult, particularly in early stages of the disease, and largely consists of pen and paper tests and brain scans. StrataStem has developed a way of creating brain cells from blood cells to model the disease. They can now make working brain cells from your donated blood cells, so all you need to give is a blood sample. They will then study the genes involved in dementia. The overall aim of the research is to help us understand the biology behind Alzheimer’s disease and, potentially, identify new drugs to treat the disease.

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  • The READ-OUT study

    Real World Dementia Outcomes: observational study

    Blood-based biomarker tests have demonstrated promising results in terms of both detecting dementia pathology and assessing the risk for developing dementia in ageing adults. In this study, we will check how good these blood tests are in terms of supporting a dementia diagnosis, how well they perform in a real-world population, and whether they are good value for money for the NHS.

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